Sentobiox

Coution is advised for each following situations:
Pre-existing hepatic and renal impairment, Fluid retention, Pulmonary edema, Decreased sperm counts, Decreases in hemoglobin and hematocrit.
Monitor hemoglobin and hematocrit levels and liver trans aminases monthly, then every 3 months thereafter. Pregnancy test must be execersied each month.
Hepatic and renal adverse reactions of Bosentan may be worsen in geriatrics