Brand Name:

Lamobiogine^®

Dosage:

25 mg & 50 mg & 100 mg

Generic Name:

Lamotrigine

Pharmacotherapeutic Group:

Anticonvulsant

Therapeutic Indication:

Lamotrigine: Epilepsy: Adjunctive therapy in the treatment of partial seizures in adults and as adjunctive therapy in the generalized seizures of Lennox-Gastaut syndrome in pediatric and adult patients. Conversion to monotherapy in adults with partial seizures who are receiving treatment with a single enzyme-inducing AED (EIAED).
May be useful in adults with generalized tonic-clonic, absence, atypical absence, and myoclonic seizures.

Dosage and Administration:

Lamotrigine Plus AED Regimen Containing Valproic Acid:

• CHILDREN (2 to 12 yr): PO Wk 1 and 2: 0.15 mg/kg/day in 1 to 2 divided doses. Wk 3 and 4: 0.3 mg/kg/day in 1 to 2 divided doses. Maintenance dose: 1 to 5 mg/kg/day (max 200 mg/day in 1 to 2 divided doses).
• ADULTS (> 12 yr): PO Wk 1 and 2: 25 mg every other day. Wk 3 and 4: 25 mg once a day. Maintenance dose: 100 to 400 mg/day in 1 to 2 divided doses. To achieve, escalate dose by 25 to 50 mg/day q 1 to 2 wk.

Lamotrigine Plus EIAEDs without Valproic Acid:

• CHILDREN (2 to 12 yr): PO Wk 1 and 2: 0.6 mg/kg/day in 2 divided doses. Wk 3 and 4: 1.2 mg/kg/day in 2 divided doses. Maintenance dose: 5 to 15 mg/kg/day (max 400 mg/day in 2 divided doses).
• ADULTS (> 12 yr): PO Wk 1 and 2: 50 mg/day. Wk 3 and 4: 100 mg/day in 2 divided doses. Maintenance dose: 300 to 500 mg/day in 2 divided doses. To achieve, escalate dose by 100 mg/day q wk.
• Patients receiving multi-drug regimens employing EIAEDs without valproic acid can have a maintenance dose of lamotrigine as high as 700 mg/day. With valproic acid, maintenance doses as high as 200 mg/day have been used. Patients receiving valproic acid and lamotrigine as a 2-drug regimen only cannot be given a safe and effective dose.

Side Effects:

• CNS: Dizziness; ataxia; somnolence; tremor; depression; anxiety; headache; insomnia; convulsions; irritability; incoordination.
• DERMATOLOGIC: Rash (can be life threatening); pruritis; sweating.
• GI: Nausea; vomiting; diarrhea; dyspepsia; constipation; abdominal pain; anorexia.
• GU: Dysmenorrhea; vaginitis; amenorrhea; urinary tract infection.
• RESPIRATORY: Rhinitis; pharyngitis; bronchitis; pneumonia.
• OTHER: Flu syndrome; fever; neck pain; diplopia; blurred vision; Stevens-Johnson syndrome