Brand Name:

Biosamide^®

Dosage:

50 mg & 100 mg

Generic Name:

Zonisamide

Pharmacotherapeutic Group:

Anticonvulsant

Therapeutic Indication:

Zonisamide: Adjunctive therapy in the treatment of partial seizures in adult epileptic patients.

Dosage and Administration:

Adults (over 16 yr): PO 100 mg/day initially, then the dose may be increased by 100 mg/day at intervals of at least 2 wk (max, 600 mg/day).

Side Effects:

• CV: Vascular insufficiency; atrial fibrillation; heart failure; ventricular extrasystoles.
• CNS: Somnolence; dizziness; headache; agitation; irritability; fatigue; tiredness; difficulty concentrating; memory difficulty; mental slowing; ataxia; paresthesia; confusion; depression; insomnia; anxiety; nervousness; schizophrenic/schizophreniform behavior; speech abnormalities; difficult verbal expression; tremor; convulsion; abnormal gait; hyperesthesia; incoordination.
• DERM: Rash; pruritus.
  EENT: Nystagmus; diplopia; taste perversion; amblyopia; tinnitus.
• GI: Nausea; anorexia; vomiting; abdominal pain; diarrhea; dyspepsia; constipation; dry mouth.
• HEM: Ecchymosis; leukopenia; anemia; lymphadenopathy; thrombocytopenia; microcytic anemia. HEPATIC: Increased ALT and AST.
• METABOLIC: Weight loss.
• RESP: Rhinitis; pulmonary embolus; pharyngitis; increased cough.
• OTHER: Flu syndrome; asthenia.