CNS

Zyprobiox®

Brand Name:

Zyprobiox®

Dosage:

2.5 mg & 5 mg & 10 mg & 15 mg

Generic Name:

Olanzapine

Pharmacotherapeutic Group:

Antipsychotic

Therapeutic Indication:

Olanzapine: Treatment of schizophrenia;
Short-term treatment of acute manic episodes with bipolar I disorder.

Dosage and Administration:

  • Schizophrenia:
    ADULTS: PO Start with 5 to 10 mg/day and adjust dosage at 5 mg increments in intervals of greater than 1 wk (safety of doses at least 20 mg/day have not been evaluated).

  • Biopolar Mania:
    ADULTS: PO Start with 10 to 15 mg/day and adjust at 5 mg increments in intervals greater than 24 hr (safety of doses more than 20 mg/day have not been evaluated).

Side Effects:

  • CV: Hypotension; tachycardia.
  • CNS: Somnolence; agitation; insomnia; nervousness; hostility; akathisia; amnesia; impairment of articulation;
  • uphoria; stuttering; tardive dyskinesia; anxiety; twitching.
  • DERM: Rash.
  • EENT: Amblyopia; blepharitis; corneal lesion.
  • GI: Constipation; dry mouth; salivation; nausea; vomiting; increased appetite.
  • GU: Premenstrual syndrome; hematuria; metrorrhagia; urinary incontinence.
  • HEP: Increased LFTs.
  • METABOLIC: Weight gain; peripheral edema; lower extremity edema.
  • RESP: Rhinitis; cough; pharyngitis; dyspnea.
  • OTHER: Headache; flu-like syndrome; fever; dizziness; joint and muscle aches.

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