Lamobiogine
Generic Name:
Lamotrigine
Pharmacotherapeutic Group:
Anticonvulsant
Therapeutic Indication:
Epilepsy: Adjunctive therapy in the treatment of partial seizures in adults and as adjunctive therapy in the generalized seizures of Lennox-Gastaut syndrome in pediatric and adult patients. Conversion to monotherapy in adults with partial seizures who are receiving treatment with a single enzyme-inducing AED (EIAED).
May be useful in adults with generalized tonic-clonic, absence, atypical absence, and myoclonic seizures.
Dosage and Administration:
Lamotrigine Plus AED Regimen Containing Valproic Acid:
CHILDREN (2 to 12 yr): PO Wk 1 and 2: 0.15 mg/kg/day in 1 to 2 divided doses. Wk 3 and 4: 0.3 mg/kg/day in 1 to 2 divided doses. Maintenance dose: 1 to 5 mg/kg/day (max 200 mg/day in 1 to 2 divided doses).
ADULTS (> 12 yr): PO Wk 1 and 2: 25 mg every other day. Wk 3 and 4: 25 mg once a day. Maintenance dose: 100 to 400 mg/day in 1 to 2 divided doses. To achieve, escalate dose by 25 to 50 mg/day q 1 to 2 wk.
Lamotrigine Plus EIAEDs without Valproic Acid:
CHILDREN (2 to 12 yr): PO Wk 1 and 2: 0.6 mg/kg/day in 2 divided doses. Wk 3 and 4: 1.2 mg/kg/day in 2 divided doses. Maintenance dose: 5 to 15 mg/kg/day (max 400 mg/day in 2 divided doses).
ADULTS (> 12 yr): PO Wk 1 and 2: 50 mg/day. Wk 3 and 4: 100 mg/day in 2 divided doses. Maintenance dose: 300 to 500 mg/day in 2 divided doses. To achieve, escalate dose by 100 mg/day q wk.
Patients receiving multi-drug regimens employing EIAEDs without valproic acid can have a maintenance dose of lamotrigine as high as 700 mg/day. With valproic acid, maintenance doses as high as 200 mg/day have been used. Patients receiving valproic acid and lamotrigine as a 2-drug regimen only cannot be given a safe and effective dose.
Side Effects:
CNS: Dizziness; ataxia; somnolence; tremor; depression; anxiety; headache; insomnia; convulsions; irritability; incoordination.
DERMATOLOGIC: Rash (can be life threatening); pruritis; sweating.
GI: Nausea; vomiting; diarrhea; dyspepsia; constipation; abdominal pain; anorexia.
GU: Dysmenorrhea; vaginitis; amenorrhea; urinary tract infection.
RESPIRATORY: Rhinitis; pharyngitis; bronchitis; pneumonia.
OTHER: Flu syndrome; fever; neck pain; diplopia; blurred vision; Stevens-Johnson syndrome.
Shelf life and Price:
Price:
Lamobiogine 25mg tablets; 30000 rls. , packs of five push – back blisters, each containing 20 scored tablets. Shelf life: 2 years.
Lamobiogine 50mg tablets; 50000 rls. , packs of five push – back blisters, each containing 20 scored tablets. Shelf life: 3 years.
Lamobiogine 100mg tablets; 54000 rls. , packs of five push – back blisters, each containing 12 scored tablets. Shelf life: 3 years.
Zyprobiox
Generic Name:
Olanzapine
Pharmacotherapeutic Group:
Antipsychotic
Therapeutic Indication:
Treatment of schizophrenia;
Short-term treatment of acute manic episodes with bipolar I disorder.
Dosage and Administration:
Schizophrenia:
ADULTS: PO Start with 5 to 10 mg/day and adjust dosage at 5 mg increments in intervals of greater than 1 wk (safety of doses at least 20 mg/day have not been evaluated).
Biopolar Mania:
ADULTS: PO Start with 10 to 15 mg/day and adjust at 5 mg increments in intervals greater than 24 hr (safety of doses more than 20 mg/day have not been evaluated).
Side Effects:
CV: Hypotension; tachycardia.
CNS: Somnolence; agitation; insomnia; nervousness; hostility; akathisia; amnesia; impairment of articulation; euphoria; stuttering; tardive dyskinesia; anxiety; twitching.
DERM: Rash.
EENT: Amblyopia; blepharitis; corneal lesion.
GI: Constipation; dry mouth; salivation; nausea; vomiting; increased appetite.
GU: Premenstrual syndrome; hematuria; metrorrhagia; urinary incontinence.
HEP: Increased LFTs.
METABOLIC: Weight gain; peripheral edema; lower extremity edema.
RESP: Rhinitis; cough; pharyngitis; dyspnea.
OTHER: Headache; flu-like syndrome; fever; dizziness; joint and muscle aches.
Price:
Zyprobiox 2.5mg tablets; 18000 rls. , packs of three push – back blisters, each containing 20 scored tablets. Zyprobiox 5mg tablets; 24000rls. , packs of five push – back blisters, each containing 12 scored tablets.
Zyprobiox 10mg tablets; 15000 rls. , packs of three push – back blisters, each containing 10 scored tablets.
Zyprobiox 15mg tablets; 18000 rls. , packs of three push – back blisters, each containing 10 scored tablets.
Risbiodal
Generic Name:
Risperidone
Pharmacotherapeutic Group:
Antipsychotic
Therapeutic Indication:
Risbiodal is indicated for the management of psychotic disorders. (it appears to produce significant improve in both the positive and negative symptoms of schizophrenia).
Dosage and Administration:
Adults: PO 1 mg bid on first day, 2 mg bid on second day, and 3 mg bid on third day. Dosage adjustment thereafter should occur at intervals of at least 1 wk in increments of 1 mg bid. Maximum effect generally occurs in a range of 4 to 8 mg/day (max, 16 mg/day).
Side Effects:
CV: Orthostatic hypotension; tachycardia; palpitations; hypertension; cardiac arrhythmias; syncope; angina pectoris; lightheadedness; ECG changes.
CNS: Tardive dyskinesia; extrapyramidal symptoms such as pseudoparkinsonism, akathisia, and dystonias; drowsiness; increased sleep duration; headache; insomnia; agitation; anxiety; aggressive reaction; dizziness; seizure.
DERM: Rash; dry skin; seborrhea; photosensitivity.
EENT: Abnormal vision/accommodation; tinnitus; rhinitis; sinusitis; pharyngitis.
GI: Constipation; nausea; dyspepsia; vomiting; abdominal pain; increased salivation; toothache; anorexia; reduced salivation.
GU: Menorrhagia; orgasmic dysfunction; dry vagina; erectile dysfunction. HEMATOLOGIC: Epistaxis; purpura; anemia.
HEP: Hepatic failure; hepatitis.
METABOLIC: Increased AST and ALT.
RESP: Coughing; upper respiratory tract infection; shortness of breath.
OTHER: Arthralgia; back pain; chest pain; fever; polyuria or polydipsia; increased weight; elevated prolactin levels.
Price:
Risbiodal 1mg tablets; 83,000 rls. , packs of five push – back blisters, each containing 12 scored tablets.
Risbiodal 2mg tablets; 12,100 rls. , packs of five push – back blisters, each containing 12 scored tablets.
Risbiodal 3mg tablets; 4,950 rls. , packs of three push – back blisters, each containing 10 scored tablets.
Risbiodal 4mg tablets; 6,300 rls. , packs of three push – back blisters, each containing 10 scored tablets.
Biovoxamine
Generic Name:
Fluvoxamine maleate
Pharmacotherapeutic Group:
Selective Serotonin Reuptake Inhibitor
Therapeutic Indication:
Treatment of obsessive-compulsive disorder as defined in DSM-III-R.
Dosage and Administration:
ADULTS: PO 50 mg as a single dose at bedtime initially. Usual range: 100 to 300 mg/day. Increase dose in 50 mg increments q 4 to 7 days, as tolerated. Give total daily doses > 100 mg in 2 divided doses;
Side Effects:
CV: Palpitations; vasodilation.
RESP: Upper respiratory infection; dyspnea; yawning.
CNS: Headache; somnolence; insomnia; nervousness; dizziness; tremor; anxiety; hypertonia; agitation; decreased libido; depression; stimulation.
EENT: Taste perversion; amblyopia.
GI: Nausea; vomiting; diarrhea; constipation; dyspepsia; anorexia; flatulence; tooth disorders; dysphagia; dry mouth.
GU: Abnormal ejaculation; urinary frequency; impotence; anorgasmia; urinary retention.
DERM: Sweating; rash; hives.
OTHER: Asthenia; flu syndrome; chills.
Shelf life and Price:
Shelf life: 2years.
Price:
Biovuxamine 50mg scored F.C. tablets; 46200rls., packs of 3 push back blisters, each containing 10 tablets.
Biovuxamine 100mg scored F.C. tablets; 90000rls., packs of 3 push back blisters, each containing 10 tablets.
Sertrabiol
Generic Name:
Sertraline
Pharmacotherapeutic Group:
Selective Serotonin Reuptake Inhibitor
Therapeutic Indication:
Treatment of depression; treatment of obsessions and compulsions in patients with obsessive-compulsive disorder (OCD), as defined in the DSM-IV; treatment of panic disorder with or without agoraphobia, as defined in DSM-IV; posttraumatic stress disorder (PTSD).
Dosage and Administration:
Depression
ADULTS: PO 50 to 200 mg once daily.
OCD
ADULTS: PO 50 to 200 mg once daily.
CHILDREN: PO Initiate dosage with 25 mg once daily (ages 6 to 12 yr) and 50 mg once daily in adolescents (ages 13 to 17 yr) in the morning or evening. Patients not responding to an initial dose of 25 or 50 mg/day may benefit from dose increases up to a max of 200 mg/day.
Panic Disorder and PTSD
ADULTS: PO 25 mg once daily; after 1 wk, increase the dose to 50 mg once daily. Patients not responding to 50 mg dose may benefit from dose increases up to a max of 200 mg/day; however, dose changes should not occur at intervals < 1 wk.
Side Effects:
CV: Palpitations; hot flushes; hypotension (postural); hypertension; syncope; tachycardia; chest pain.
CNS: Agitation; anxiety; nervousness; headache; insomnia; dizziness; tremor; fatigue; tingling; diminished sensation; twitching; hypertonia; decreased concentration; confusion; somnolence; nervousness; depression; decreasedlibido; agitation; emotional lability; vertigo; hypoesthesia; apathy; hypo-/hyperkinesia; abnormal dreams.
DERM: Sweating, rash; pruritus; acne.
EENT: Abnormal vision; ringing in the ears; rhinitis; pharyngitis; change in taste perception.
GI: Nausea; diarrhea; dry mouth; anorexia; vomiting; flatulence; constipation; abdominal pain; increased appetite; dyspepsia; gastroenteritis; tooth disorder/caries; dysphagia; melena.
GU: Sexual dysfunction; urinary frequency; urinary disorder; menstrual disorder; pain; abnormal ejaculation.
HEM: Lymphadenopathy; purpura.
METABOLIC: Dehydration; hypoglycemia.
RESP: Upper respiratory tract infection; pharyngitis; sinusitis; increased cough; dyspnea; bronchitis; rhinitis;
OTHER: Muscle pain; weight loss or gain; myalgia; arthralgia; asthenia; fever; allergy/allergic reaction; chills; back pain; malaise; edema.
Price:
Sertrabiol 50 mg tablets; 30,000 rls. , packs of three push – back blisters, each containing 20 scored tablets.
Sertrabiol 100 mg tablets; 27,000 rls. , packs of three push – back blisters, each containing 10 scored tablets.
Bioxal
Generic Name:
Citalopram
Pharmacotherapeutic Group:
Selective Serotonin Reuptake Inhibitor
Therapeutic Indication:
Treatment of depression; treatment of obsessions and compulsions in patients with obsessive-compulsive disorder (OCD), as defined in the DSM-IV; treatment of panic disorder with or without agoraphobia, as defined in DSM-IV; posttraumatic stress disorder (PTSD).
Dosage and Administration:
Depression
ADULTS: PO 50 to 200 mg once daily.
OCD
ADULTS: PO 50 to 200 mg once daily.
CHILDREN: PO Initiate dosage with 25 mg once daily (ages 6 to 12 yr) and 50 mg once daily in adolescents (ages 13 to 17 yr) in the morning or evening. Patients not responding to an initial dose of 25 or 50 mg/day may benefit from dose increases up to a max of 200 mg/day.
Panic Disorder and PTSD
ADULTS: PO 25 mg once daily; after 1 wk increase the dose to 50 mg once daily. Patients not responding to 50 mg dose may benefit from dose increases up to a max of 200 mg/day; Dose changes should not occur at intervals < 1 wk.
Side Effects:
CV: Palpitations; hot flushes; hypotension (postural); hypertension; syncope; tachycardia; chest pain.
CNS: Agitation; anxiety; nervousness; headache; insomnia; dizziness; tremor; fatigue; tingling; diminished sensation; twitching; hypertonia; decreased concentration; confusion; somnolence; nervousness; depression; decreasedlibido; agitation; emotional lability; vertigo; hypoesthesia; apathy; hypo-/hyperkinesia; abnormal dreams. DERM: Sweating, rash; pruritus; acne.
EENT: Abnormal vision; ringing in the ears; rhinitis; pharyngitis; change in taste perception.
GI: Nausea; diarrhea; dry mouth; anorexia; vomiting; flatulence; constipation; abdominal pain; increased appetite; dyspepsia; gastroenteritis; tooth disorder/caries; dysphagia; melena.
GU: Sexual dysfunction; urinary frequency; urinary disorder; menstrual disorder; pain; abnormal ejaculation.
HEM: Lymphadenopathy; purpura.
METABOLIC: Dehydration; hypoglycemia.
RESP: Upper respiratory tract infection; pharyngitis; sinusitis; cough; dyspnea; bronchitis; rhinitis; yawn.
OTHER: Muscle pain; weight loss or gain; myalgia; arthralgia; asthenia; fever; allergy/allergic reaction; chills; back pain; malaise; edema.
Price:
Bioxal 20 mg tablets; 48,000 rls. , packs of three push – back blisters, each containing 20 scored tablets.
Bioxal 40 mg tablets; 84,000 rls. , packs of three push – back blisters, each containing 20 scored tablets.
Biosamide
Generic Name:
Zonisamide
Pharmacotherapeutic Group:
Anticonvulsant
Therapeutic Indication:
Adjunctive therapy in the treatment of partial seizures in adult epileptic patients.
Dosage and Administration:
Adults (over 16 yr): PO 100 mg/day initially, then the dose may be increased by 100 mg/day at intervals of at least 2 wk (max, 600 mg/day).
Side Effects:
CV: Vascular insufficiency; atrial fibrillation; heart failure; ventricular extrasystoles.
CNS: Somnolence; dizziness; headache; agitation; irritability; fatigue; tiredness; difficulty concentrating; memory difficulty; mental slowing; ataxia; paresthesia; confusion; depression; insomnia; anxiety; nervousness; schizophrenic/schizophreniform behavior; speech abnormalities; difficult verbal expression; tremor; convulsion; abnormal gait; hyperesthesia; incoordination.
DERM: Rash; pruritus.
EENT: Nystagmus; diplopia; taste perversion; amblyopia; tinnitus.
GI: Nausea; anorexia; vomiting; abdominal pain; diarrhea; dyspepsia; constipation; dry mouth.
HEM: Ecchymosis; leukopenia; anemia; lymphadenopathy; thrombocytopenia; microcytic anemia.
HEPATIC: Increased ALT and AST.
METABOLIC: Weight loss.
RESP: Rhinitis; pulmonary embolus; pharyngitis; increased cough.
OTHER: Flu syndrome; asthenia.
Shelf life and Price:
Biosamide 50mg Capsules; packs of 3 push back blisters, each containing 10 capsules.
Biosamide 100mg scored Capsules; 60000 rls., packs of 3 push back blisters, each containing 10 capsules.
Biopentine
Generic Name:
Gabapentin
Pharmacotherapeutic Group:
Anticonvulsant
Therapeutic Indication:
Adjunctive therapy in treatment of partial seizures with or without secondary generalization in patients above 12 yr with epilepsy. Adjunctive therapy for partial seizures in children 3 to 12 yr. management of postherpetic neuralgia in adults.
Dosage and Administration:
Epilepsy
ADULTS AND CHILDREN ABOVE 12 YR: PO 900 to 1800 mg/day in divided doses tid. Initial dose: 300 mg on day 1 and titrate upward rapidly.
CHILDREN 3 TO 12 YR: PO Initiate therapy at 10 to 15 mg/kg/day in divided doses (ie, 3 times/day) and titrate dose upward over a period of about 3 days to the effective dose.
CHILDREN AT LEAST 5 YR: PO The effective dose is 25 to 35 mg/kg/day in divided doses.
CHILDREN 3 TO 4 YR: PO The effective dose is 40 mg/kg/day in divided doses.
Postherpetic Neuralgia
ADULTS: PO Start with a single 300 mg dose on day 1, 600 mg on day 2 (divided twice daily), and 900 mg on day 3 (divided 3 times daily). Subsequently, titrate the dose upward as needed for pain relief to a daily dose of 1800 mg (divided 3 times daily).
Side Effects:
CV: Hypertension.
CNS: Somnolence; dizziness; ataxia; tremor; nervousness; dysarthria; amnesia; depression; abnormal thinking; twitching; abnormal coordination; vertigo; hyperkinesia; parasthesia; reflex abnormality; hostility; anxiety.
DERM: Pruritus; abrasion; purpura.
EENT: Diplopia; amblyopia; nystagmus; abnormal vision; gingivitis.
GI: Dyspepsia; dry mouth or throat; constipation; dental abnormalities; increased appetite; anorexia; flatulence.
RESP: Rhinitis; pharyngitis; coughing; pneumonia.
OTHER: Fatigue; weight increase; back pain; peripheral edema; impotence; leukopenia; vasodilation; asthenia; malaise; facial edema; arthralgia.
Shelf life and Price:
Shelf life: 2years.
Price:
Biopentin 100mg Capsules; 24000rls., packs of 3 push back blisters, each containing 10 capsules.
Biopentin 300mg Capsules; 63000rls., packs of 3 push back blisters, each containing 10 capsules.
Biopentin 400mg Capsules; 81000rls., packs of 3 push back blisters, each containing 10 capsules.
